Scientists Achieve Medical Breakthrough in Aging Treatment.. Initial Success in Mice
November 29, 2025810 ViewsRead Time: 2 minutes
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A team of scientists has announced a new medical breakthrough that could pave the way for aging treatment, following initial success in experiments on mice. Researchers hope these results will soon open the door to clinical trials in humans, aimed at combating aging and maintaining youthful vitality.
The Cause of Aging
As people age, the productivity of blood-forming stem cells decreases, affecting the immune system and increasing the risk of diseases such as anemia and cancer.
According to a report published by Science Alert, scientists have discovered a way to restore these cells to their normal state, which may help treat issues related to blood deficiency and age-related immune weakness.
The Role of Lysosomes
Researchers explained that irritated stem cells contain small parts known as lysosomes, which act as the cell's recycling centers, breaking down proteins and fats into reusable components.
A joint study between the Icahn School of Medicine at Mount Sinai in the United States and Paris City University indicated that aging causes functional impairment in lysosomes in blood-forming stem cells, leading to their hyperactivity compared to young cells.
The Experiment on Mice
Sagi Ghafari, a stem cell biologist, conducted experiments on aging mice and found that the lysosomes in their cells suffered from excessive acidity and dysfunction, reducing the cells' ability to regenerate.
By using a chemical called Concanamycin A, the team successfully calmed the lysosomes and restored their acidity and activity to normal levels.
The Results
After treating the stem cells taken from the mice and returning them to their bodies, the tissues' ability to produce new blood cells increased eightfold. The treated cells exhibited more youthful behavior, resuming their ability to regenerate and produce balanced blood cells.
Ghafari confirmed that the results indicate that aging in blood stem cells is not a final destiny, and these cells can return to a youthful state by targeting lysosomal hyperactivity, improving blood cell renewal and immune system functions.
The Cause of Aging
As people age, the productivity of blood-forming stem cells decreases, affecting the immune system and increasing the risk of diseases such as anemia and cancer.
According to a report published by Science Alert, scientists have discovered a way to restore these cells to their normal state, which may help treat issues related to blood deficiency and age-related immune weakness.
The Role of Lysosomes
Researchers explained that irritated stem cells contain small parts known as lysosomes, which act as the cell's recycling centers, breaking down proteins and fats into reusable components.
A joint study between the Icahn School of Medicine at Mount Sinai in the United States and Paris City University indicated that aging causes functional impairment in lysosomes in blood-forming stem cells, leading to their hyperactivity compared to young cells.
The Experiment on Mice
Sagi Ghafari, a stem cell biologist, conducted experiments on aging mice and found that the lysosomes in their cells suffered from excessive acidity and dysfunction, reducing the cells' ability to regenerate.
By using a chemical called Concanamycin A, the team successfully calmed the lysosomes and restored their acidity and activity to normal levels.
The Results
After treating the stem cells taken from the mice and returning them to their bodies, the tissues' ability to produce new blood cells increased eightfold. The treated cells exhibited more youthful behavior, resuming their ability to regenerate and produce balanced blood cells.
Ghafari confirmed that the results indicate that aging in blood stem cells is not a final destiny, and these cells can return to a youthful state by targeting lysosomal hyperactivity, improving blood cell renewal and immune system functions.
