Medical Breakthrough: Single Dose to Eradicate AIDS

Researchers have succeeded in developing a vaccine against the human immunodeficiency virus, HIV, that can support the body with just one dose to combat the disease. This was achieved through a combination of drugs that help achieve a strong immune response.


The fundamental study was conducted by researchers from the Massachusetts Institute of Technology and the Scripps Research Institute, and its results showed that the vaccine produced a strong immune response in mice, thanks to the ability of two types of adjuvants to enhance antibodies.



The study was published in the journal Science Translational Medicine, where researchers used an antibody to the HIV protein linked to aluminum hydroxide particles.

An antibody to the virus protein is a protein present on the surface of the virus (or inside it) that triggers an immune response when it enters the human body. The immune system recognizes it and produces antibodies against it.

Previous studies have shown that combining these two stimulants yields stronger results when used together.


After injecting the mice with the composite vaccine, it was observed that the vaccine remained in the lymph nodes and stayed there for a month, allowing more time for the formation of effective antibodies.

According to the report, this combination can enhance the likelihood of generating neutralizing antibodies, which are essential for combating constantly changing viruses like HIV.

Professor Christopher Love from the Massachusetts Institute of Technology says that this approach is not limited to HIV only, but can also be used to develop more effective vaccines against diseases like influenza, COVID, and SARS with just one dose.